研究興趣

1.臨床病原細(xì)菌對(duì)β-內(nèi)酰胺類藥物、多粘菌素類藥物和替加環(huán)素耐藥機(jī)制研究

2.結(jié)核分枝桿菌耐藥機(jī)制研究

3.耐藥基因的分子生物學(xué)檢測(cè)方法建立

4.細(xì)菌耐藥阻斷劑和新型抗生素復(fù)方制劑研發(fā)

主要學(xué)術(shù)任職

1.中國微生物學(xué)會(huì)醫(yī)學(xué)微生物學(xué)與免疫學(xué)專委會(huì)第一屆青年委員會(huì)委員

2.中國防癆協(xié)會(huì)青年理事會(huì)委員

3.全國高等教育醫(yī)學(xué)數(shù)字化規(guī)劃教材《醫(yī)學(xué)微生物學(xué)》編委

4.美國微生物學(xué)會(huì)(American Society for Microbiology，ASM)會(huì)員

5.國家和廣東省自然科學(xué)基金項(xiàng)目評(píng)審專家

6.Clinical Infectious Diseases、Journal of Antimicrobial Chemotherapy 、Antimicrobial Agents and Chemotherapy、Clinical Microbiology and Infection、Oncotarget等雜志審稿專家

科研項(xiàng)目

1. “廣東特支計(jì)劃”百千萬工程青年拔尖人才，2016，細(xì)菌耐藥性

2.高?；究蒲袠I(yè)務(wù)費(fèi)青年教師重點(diǎn)培育項(xiàng)目，16ykzd09，耐碳青霉稀類藥物“超級(jí)細(xì)菌”的耐藥傳播分子機(jī)制及臨床治療，主持

3.國家自然科學(xué)基金項(xiàng)目，81471988，新型超廣譜β-內(nèi)酰胺酶PME耐藥傳播分子機(jī)制，主持

4.國家重點(diǎn)研發(fā)計(jì)劃，2016YFC1200100，輸入性傳染病的輸入機(jī)制與播散規(guī)律，核心骨干

5.廣東省科技發(fā)展專項(xiàng)，2016A020219002，動(dòng)物和人源產(chǎn)碳青霉烯酶超級(jí)細(xì)菌的流行病學(xué)和傳播機(jī)制比較研究，主持

6.廣州市珠江新星專項(xiàng)，2014J2200038，廣東產(chǎn)新型超廣譜β-內(nèi)酰胺酶PME耐藥傳播分子機(jī)制及風(fēng)險(xiǎn)，主持

7.廣東省自然科學(xué)基金項(xiàng)目，S2013010015810，廣東PME酶學(xué)功能及耐藥傳播分子機(jī)制，主持

8.國家重大科技專項(xiàng)“十二五”計(jì)劃課題，2013ZX10003001，結(jié)核病新型診斷產(chǎn)品研發(fā)及其產(chǎn)業(yè)化，子任務(wù)負(fù)責(zé)人

9.廣東省海洋經(jīng)濟(jì)創(chuàng)新發(fā)展區(qū)域示范專項(xiàng)項(xiàng)目，GDHY2012-01-001，海洋生物天然產(chǎn)物化合物庫，參與

10.國家自然科學(xué)基金項(xiàng)目，81201325，產(chǎn)CTX-M-15多重耐藥E.coliST131耐藥傳播分子機(jī)制研究，主持

11.廣東省自然科學(xué)基金項(xiàng)目，廣東地區(qū)產(chǎn)CTX-M-15多重耐藥E.coliST131耐藥傳播分子機(jī)制研究，主持

獲獎(jiǎng)情況

1.廣州市珠江科技新星

2.高?；究蒲袠I(yè)務(wù)費(fèi)青年教師重點(diǎn)培育項(xiàng)目

3.“廣東特支計(jì)劃”百千萬工程青年拔尖人才

4.廣東省高等院校“千百十工程”第七批校級(jí)培養(yǎng)對(duì)象

5.所屬“抗感染免疫”團(tuán)隊(duì)被授予“第四屆中國僑界貢獻(xiàn)(創(chuàng)新團(tuán)隊(duì))獎(jiǎng)”

6.國家科技進(jìn)步獎(jiǎng)二等獎(jiǎng)

7.四川省科學(xué)技術(shù)進(jìn)步一等獎(jiǎng)

8.中山醫(yī)學(xué)院優(yōu)秀黨務(wù)工作者

9.中山醫(yī)學(xué)院教學(xué)質(zhì)量獎(jiǎng)

代表性論文

1.Lan-Lan Zhong，Nicole Stoesser，Yohei Doi，Cong Shen，Xi Huang，Guo-Bao Tian*（通訊作者），Carriageof β-lactamase-producing Enterobacteriaceae by Chinese travellers，Lancet Infectious Diseases，2017.2.1，17. 影響因子22.433

Yang Wang*, Guo-Bao Tian*（共同第一作者）, Rong Zhang, Yingbo Shen, Jonathan M. Tyrrell, Xi Huang, Hongwei Zhou, Lei Lei, Hong-Yu Li, Yohei Doi, Ying Fang, Hongwei Ren, Lan-Lan Zhong, Zhangqi Shen, Kun-Jiao Zeng, Shaolin Wang, Jian-Hua Liu, Congming Wu, Timothy R. Walsh, Jianzhong Shen.Clinical associations and molecular epidemiology of mcr-1-positive Escherichia coli in patients and as normal human flora from China: an epidemiology and clinical study. Lancet Infectious Diseases.accepted. 影響因子22.433

Lan-Lan Zhong, Yan-Fen Zhang, Yohei Doi, Xi Huang, Xue-Fei Zhang, Kun-Jiao Zeng, Cong She, Sandip Patil, Yong Xing, Yutian Zou, Guo-Bao Tian*（通訊作者）. Co-production of MCR-1 and NDM-1 by colistin-resistantEscherichia coli isolated from a healthy individual. Antimicrobial Agents and Chemotherapy. 2016 Nov 7. pii: AAC.01962-16. 影響因子4.451.

Zhang XF, Doi Y, Huang X, Li HY, Zhong LL, Zeng KJ, Zhang YF, Patil S, Tian GB（通訊作者）. Possible Transmission of mcr-1-Harboring Escherichia coli between Companion Animals and Human. Emerg Infect Dis. 2016 Sep 15;22(9). doi: 10.3201/eid2209.160464. 影響因子6.994.

Zeng KJ, Doi Y, Patil S, Huang X, Tian GB（通訊作者）. Emergence of the Plasmid-Mediated mcr-1 Gene in Colistin-Resistant Enterobacter aerogenes and Enterobacter cloacae. Antimicrob Agents Chemother. 2016 May 23;60(6):3862-3. doi: 10.1128/AAC.00345-16. 影響因子4.451

Tian GB（第一作者）, Jiang YQ, Huang YM, Qin Y, Feng LQ, Zhang XF, Li HY, Zhong LL, Zeng KJ, Patil S, Xing Y, Huang X. Characterization of CTX-M-140, a Variant of CTX-M-14 Extended-Spectrum β-Lactamase (ESBL) with Decreased Cephalosporin Hydrolytic Activity, from Cephalosporin-Resistant Proteus mirabilis. Antimicrob Agents Chemother. 2016 Aug 1. pii: AAC.00822-16. 影響因子4.451.

Huang YM, Zhong LL, Zhang XF, Hu HT, Li YQ, Yang XR, Feng LQ, Huang X, Tian GB（通訊作者）. NDM-1-Producing Citrobacter freundii, Escherichia coli, and Acinetobacter baumannii Identified from a Single Patient in China. Antimicrob Agents Chemother. 2015 Aug;59(8):5073-7. doi: 10.1128/AAC.04682-14.

Guo-Bao Tian（共同第一作者）, Ying-Min Huang, Zhi-Li Fang, Yun Qing, Xue-Fei Zhang, Xi Huang.CTX-M-137, a Hybrid of CTX-M-14-Like and CTX-M-15-Likeβ-Lactamases Identified in anEscherichia coliClinical Isolate.J Antimicrob Chemother. 2014;69(8):2081-5.

Qing Y, Cao KY, Fang ZL, Huang YM, Zhang XF,Tian GB（共同通訊作者）, Huang X. Outbreak of PER-1 and Diversity of β-Lactamases among Ceftazidime-ResistantPseudomonas aeruginosaClinical Isolates in China. J Med Microbiol. 2014 Jan 7. doi: 10.1099/jmm.0.069427-0.[Epub ahead of print].

Fang ZL, Zhang LY, Huang YM, Qing Y, Cao KY,Tian GB（共同通訊作者）, Huang X. OprD mutations and inactivation in imipenem-resistantPseudomonas aeruginosaisolates from China. Infect Genet Evol. 2014; 21:124-8.

Guo-Bao Tian（第一作者）, Hong-Ning Wang, An-Yun Zhang, Yi Zhang, Wen-Qiao Fan, Chang-Wen Xu, Bo Zeng, Zhong-Bin Guan, Li-Kou Zou. Detection of clinically important β-lactamases in commensal Escherichia coli of human and swine origin in western China. Journal of Medical Microbiology (ISSN: 0022-2615). 2012; 61(Pt 2):233-8.

Guo-Bao Tian（第一作者）, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, Anthony W. Pasculle, John P. Quinn, Hong-Ning Wang, Yohei Doi. Identification of Diverse OXA-40-Group Carbapenemases Including a Novel Variant, OXA-160, fromAcinetobacter baumanniiin Pennsylvania.Antimicrob Agents Chemother.2010; 55:429-32.

Guo-Bao Tian（第一作者）, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, Hong-Ning Wang, Yohei Doi. PME-1, an Extended-Spectrum β-lactamase Identified inPseudomonas aeruginosa.Antimicrob Agents Chemother. 2011; 55: 2710-2713.

Guo-Bao Tian（第一作者）, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, Yohei Doi. Sequence Type ST405Escherichia coliIsolate Producing QepA1, CTX-M-15, and RmtB from Detroit, Michigan.Antimicrob Agents Chemother. 2011; 55: 3966-3967.

Guo-Bao Tian（第一作者）, Jennifer M. Adams-Haduch, Tatiana Bogdanovich, Hong-Ning Wang, Yohei Doi. Extended-Spectrum AmpC inAcinetobacter baumanniiADC-56 Confers Resistance to cefepime.Antimicrob Agents Chemother. 2011; 55: 4922-4925.

Guo-Bao Tian（第一作者）, Wang Hong-ning, Li-Kou Zou, etc. Detection of clinically important β-lactamases in commensalEscherichia coliof human and swine origin in western China.J Med Microbiol. 2012 61(2):233-8.

Guo-Bao Tian（第一作者）, Jemelyn Garcia, Jennifer M. Adams-Haduch, Jennifer P. Evangelista, Raul V. Destura, Hong-Ning Wang, Yohei Doi. CTX-M as the predominant extended-spectrum b-Lactamase amongEnterobacteriaceaein Manila, Philippines.J Antimicrob Chemother. 2010; 65: 584-6.

Guo-Bao Tian（第一作者）, Jennifer M. Adams-Haduch, Zubair A. Qureshi, Hong-Ning Wang, Yohei Doi. CTX-M-35 Extended-Spectrum b-Lactamase Conferring Ceftazidime Resistance inCitrobacter koserii.International Journal of Antimicrobial Agents. 2010; 35: 412-3.

Guo-Bao Tian（第一作者）,Wang Hong-ning, Li-Kou Zou, etc. Detection of CTX-M-15, CTX-M-22, and SHV-2 Extended-Spectrum bata-Lactamases (ESBLs) inEscherichia coliFecal-Sample Isolates from Pig Farms in China.Foodborne Pathogens and Disease. 2009; 6:297-304.

Rongsui Gao,Yongfei Hu,Zhencui Li,Jian Sun,Qingjing Wang,Jingxia Lin,Huiyan Ye,Fei Liu,Swaminath Srinivas, Defeng Li,Baoli Zhu,Ya-Hong Liu,Guo-Bao Tian（合作作者）,Youjun Feng. Dissemination and Mechanism for the MCR-1 Colistin Resistance.PLOS Pathogens.

Yi-Yun Liu, Yang Wang, Timothy R Walsh, Ling-Xian Yi, Rong Zhang, James Spencer, Yohei Doi, Guo-bao Tian（合作作者）, Baolei Dong, Xianhui Huang, Lin-Feng Yu, Danxia Gu, Hongwei Ren, Xiaojie Chen, Luchao Lv, Dandan He, Hongwei Zhou, Zisen Liang, Jian-Hua Liu, Jianzhong Shen. Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study. Lancet Infectious Diseases (ISSN: 1473-3099). 2016; 16(2):161-8. doi: 10.1016/S1473-3099(15)00424-7.

Hanna E. Sidjabat, David L. Paterson, Jennifer M. Adams-Haduch, Lindsay Ewan, Anthony W. Pasculle, Carlene A. Muto,Guo-Bao Tian, and Yohei Doi. Molecular Epidemiology of CTX-M-ProducingEscherichia coliIsolates at a Tertiary Medical Center in Western Pennsylvania.Antimicrob Agents Chemother2009; 53: 4733-9.

Rebecca I. Waltner-Toews, David L. Paterson, Zubair A. Qureshi, Hanna E. Sidjabat, Jennifer M. Adams-Haduch, Kathleen A. Shutt, Mark Jones,Guo-Bao Tian, Anthony W. Pasculle, and Yohei Doi. Clinical Characteristics of Bloodstream Infections Due to Ampicillin/Sulbactam-Resistant, Non-ESBL-ProducingEscherichia coliand the Role of TEM-1 Hyperproduction.Antimicrob Agents Chemother. 2011; 55: 495-501.

Tatiana Bogdanovich, Jennifer M. Adams-Haduch,Guo-Bao Tian, Hong M. Nguyen, Eun J. Kwak, Carlene A. Muto, Yohei Doi. Colistin ResistantKlebsiella pneumoniaeCarbapenemase (KPC) ProducingKlebsiella pneumoniaeBelonging to the International Epidemic Clone ST258.Clinical Infectious Diseases. 2011; 53: 373-376.

Jennifer M. Adams-Haduch, Ezenwa O. Onuoha, Tatiana Bodganovich,Guo-Bao Tian, Jonas Marschall, Carl Urban, Brad Spellberg, Diane Rhee, Diane Halstead, Anthony W. Pasculle, Yohei Doi. Contemporary Molecular Epidemiology of Carbapenem-ResistantAcinetobacter baumanniiin the United States.J Clin Microbiol. 2011;49(11):3849-54.

1.

Guo-Bao Tian*

2.

*

3.

Guo-Bao Tian

4.

Tian GB

5.

Tian GB

6.

Tian GB

7.

Tian GB

8.

Guo-Bao Tian

9.

Tian GB

10.

Tian GB

11.

Guo-Bao Tian

12.

Guo-Bao Tian

13.

Guo-Bao Tian

14.

Guo-Bao Tian

15.

Guo-Bao Tian

16.

Guo-Bao Tian

17.

Guo-Bao Tian

18.

Guo-Bao Tian

19.

Guo-Bao Tian

20.

Guo-Bao Tian

21.

Guo-bao Tian

22.

Guo-Bao Tian

23.

Guo-Bao Tian

24.

Guo-Bao Tian

25.

Guo-Bao Tian

招聘信息

本實(shí)驗(yàn)室常年招聘以下研究人員：

1. 特聘研究員：38周歲以下，博士，有4項(xiàng)及以上代表性學(xué)術(shù)成果。工資稅前30-36萬/年

2. 特聘副研究員：38周歲以下，博士，有2項(xiàng)及以上代表性學(xué)術(shù)成果。工資稅前19-25萬/年

3. 助理研究員：35周歲以下，博士或特別優(yōu)秀的碩士。工資稅前14-16萬/年

4. 博士后：35周歲以下，國內(nèi)外知名高校或研究機(jī)構(gòu)的博士畢業(yè)生。工資稅前12-16萬/年

歡迎有醫(yī)學(xué)、生命科學(xué)、生物信息學(xué)等相關(guān)研究背景的人員與本人聯(lián)系。